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Source Naturals

L-Valine is one of the three branched chain amino acids. They have an important role in the detoxification of ammonia and preventing muscle wasting in Hepatic Encephalopathy patients. L-Valine reportedly has both immune enhancing and lipid clearing properties.

Bottle Contents: 100 grams of pure L-Valine, no other ingredients

Dosage and Use: Between Meals 1/8 to 1 teaspoon, 3 times daily

Bottles Needed for One-Month Supply:  2 (at the full 1 teaspoon dose)

Cautions: None

What it Does/How it Works:

L-Valine is one of three Branched-Chain Amino Acids (BCAA). It seems to have an antiviral action on its own. Japanese researchers lead by T. Kawaguchi (2012) used L-Valine for a very advanced Hepatitis C patient, giving up to 12 grams a day. Fibrosis indexes fell, platelets rose, alpha-fetoprotein level fell, and viral load fell quite low and stayed relatively low between 1.2 and 3.6 logs. The patient also felt less fatigued.

Then the researchers used interferon on its own to clear the man of the virus as the viral load was already very low from the Valine.

This research is new — having just been reported in September of 2012 — and it is only one patient, however it is worth following up on.  They started him on 3 grams of L-Valine and went up to 12 grams. When they were in the just L-Valine phase this changed the ratio of  BCAA, but that did not create any ill effects. Afterwards they gave all three BCAA in a normal ratio.

Mechanisms that the Japanese researchers found were both immune as well as on lipid metabolism. They noted increased 'lipid droplets in the liver' and triglycerides in L-Valine deficient patients. Increased triglycerides are associated with HCV replication. This suggests a positive action for L-Valine in treating fatty liver. Immune actions increased interleukin 12 production and activation of interferon signaling.

Please report back if you have any significant experiences with this product. Sometimes it takes awhile to really understand the best dosing and any feedback on what dosage worked for you is appreciated. There is no toxicity reported with these amino acids.



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